My Sisters Room, better known as MSR, is one of only a handful of lesbian bars left in the U.S. (last time we checked it was less than 25), a queer-friendly space to grab a drink or get your groove on out on the dance floor. Although their address changes frequently, MSR is always somewhere in Midtown, and they’ve always got something going on. Karaoke, dance parties, drag shows, and comedy nights are just a few of the events you’ll see on their calendar. While they do offer standard light bites like hot dogs and tacos, you’ll probably want to eat before you go so you can prioritize taking shots at the bar and dancing. Most nights it’s more of a party, but there’s a patio you can hit if you need to reset and take a break from the flashing lights upstairs.